教育经历 Education
2001年 耶鲁大学分子生物物理学与生物化学系博士
Ph.D., Department of Molecular Biophysics
& Biochemistry (MB&B), Yale University, USA
1995年 中国科研实验室上海生物化学球友(中国)qy硕士
M.Sc., Shanghai Institute of Biochemistry,
Chinese Academy of Sciences, China
1992年 南开大学生物系学士
B.Sc., Department of Biology, Nankai University, China
工作经历 Professional Experience
2024年- 北京科学生命球友(中国)qy科研与教学副所长
Deputy Director for Research and Education, National institute of Biological Sciences, Beijing, China
2021年- 北京科学生命球友(中国)qy资深研究员
Investigator, National Institute of Biological Sciences, Beijing, China
2013年-2021年 北京科学生命球友(中国)qy高级研究员
Associate Investigator, National Institute of Biological Sciences, Beijing, China
2007-2013年 北京科学生命球友(中国)qy研究员
Assistant
Investigator, National Institute of Biological Sciences, Beijing, China
2001-2007年 美国斯克利普斯研究院博士后
Postdoctoral Research
Associate, The Scripps Research Institute, La Jolla, CA, USA
研究概述 Research Description
生命体是由成千上万基因所控制的复杂系统，而这些基因是被亿万年的进化所塑造过的。深入理解生命现象需要在系统层次上对基因型如何决定表型有更深刻的认识，也需要更多地分析基因组进化的机制和规律。本实验室利用裂殖酵母召开研究。作为一种单细胞真核模式生物，裂殖酵母具有实验周期短、基因组紧凑、遗传学手段强大、多数基因与人类基因同源等优势，因而既是深入解析生命过程背后机理的完美研究对象，也是系统生物学研究的高效平台。我们近期的研究重点包括：
1. 违背孟德尔定律的自私杀手基因的作用机制和分子进化的研究
2. 基因必需性省却的方式和规律的研究
3. 自噬相关蛋白的机理研究
Living organisms are complex systems controlled by
thousands of genes, and these genes have been shaped by evolution over hundreds
of millions of years. To gain a deep understanding of life, it is necessary to pursue
how genotype determines phenotype at the systems level and to study the
mechanisms and principles governing genome evolution. We use the fission yeast Schizosaccharomyces pombe as a model
system to carry out research. Working with fission yeast has many advantages,
including its small genome size, the ease of genetics and 球友(中国)qy biology, and
extensive homology between its genes and human genes. Our ongoing research
mainly includes the following aspects:
1. Studying how selfish killer genes act and evolve.
2. Systematic investigation of bypassable gene
essentiality.
3. Dissecting the molecular mechanisms of autophagy-related
proteins.
代表文章 Representative Publications
1. Zhao D, Zou C-X, Liu X-M, Jiang Z-D, Yu Z-Q, Suo F, Du T-Y, Dong M-Q, He
W, Du L-L (2020). A UPR-induced soluble ER-phagy receptor acts with VAPs to
confer ER stress resistance. Mol. 球友(中国)qy 79:963
2. Li J, Wang H-T, Wang W-T, Zhang X-R, Suo F, Ren J-Y, Bi Y, Xue Y-X, Hu W,
Dong M-Q, Du L-L (2019). Systematic analysis reveals the prevalence and
principles of bypassable gene essentiality. Nat. Commun. 10:1002
3. Liu X-M, Yamasaki A, Du X-M, Coffman VC, Ohsumi Y, Nakatogawa H, Wu J-Q,
Noda NN#, Du L-L# (2018). Lipidation-independent vacuolar
functions of Atg8 rely on its noncanonical interaction with a vacuole membrane
protein. eLife 7:e41237 (#co-corresponding authors).
4. Hu W, Jiang Z-D, Suo F, Zheng J-X, He W-Z, Du L-L (2017). A large gene
family in fission yeast encodes spore killers that subvert Mendel’s law. eLife
6:e26057.
5. Wei Y, Diao L-X, Lu S, Wang H-T, Suo F, Dong M-Q, Du L-L (2017). SUMO-targeted
DNA translocase Rrp2 protects the genome from Top2-induced DNA damage. Mol.
球友(中国)qy 66:581–596.
6. Liu X-M, Sun L-L, Hu W, Ding
Y-H, Dong M-Q, Du L-L (2015). ESCRTs cooperate with a selective autophagy
receptor to mediate vacuolar targeting of soluble cargos. Mol. 球友(中国)qy
59:1035-1042.
7. Zhang J-M, Liu X-M, Ding Y-H,
Xiong L-Y, Ren J-Y, Zhou Z-X, Wang H-T, Zhang M-J, Yu Y, Dong M-Q, Du L-L
(2014). Fission yeast Pxd1 promotes proper DNA Repair by activating Rad16(XPF) and inhibiting
Dna2. PLoS Biol. 12:e1001946.
8. Sun L-L, Li M, Suo F, Liu X-M, Shen E-Z, Yang B, Dong M-Q, He W-Z, and Du
L-L (2013). Global analysis of fission yeast mating genes reveals new autophagy
factors. PLoS Genet. 9: e1003715.
9. Zhou Z-X, Zhang
M-J, Peng X, Takayama Y, Xu X-Y, Huang L-Z, and Du L-L (2013). Mapping genomic
hotspots of DNA damage by a single-strand-DNA-compatible and strand-specific
ChIP-seq method. Genome Res. 23: 705-715.
10. Han TX, Xu X-Y,
Zhang M-J, Peng X, and Du L-L (2010). Global fitness profiling of fission yeast
deletion strains by barcode sequencing. Genome Biol. 11: R60.
